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I don’t know anything about programming, so I can’t put it into the game and the game is not complete anyway, so it looks pointless to me. Since they never completed their fan game, naturally there was no English translation. Their group in VK (Russian Facebook) stopped responding to any messages and no updates have been posted there for two years. the group of enthusiasts who made it ceased to exist. The problem is that they only released the first chapter of a new game, and after that. Artech House cannot attest to the accuracy of this information. All terms mentioned in this book that are known to be trademarks or service marks have been appropriately capitalized. No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the publisher. Printed and bound in the United States of America. 685 Canton Street Norwood, MA 02062 All rights reserved. Engineering mathematics-Computer programs I. TA345.T63 1996 620’.00285’53-dc20 96-19492 CIP British Library Cataloguing in Publication Data Tocci, Chris Appled Maple for engineers and scientists 1. Includes bibliographical references and index. Applied Maple for engineers and scientists / Chris Tocci and Steve Adams. Library of Congress Cataloging-in-Publication Data Tocci, Christopher. Applied Maple for Engineers and ScientistsĪpplied Maple for Engineers and Scientists Chris Tocci In a confirmatory study you have to specify the weighting scheme beforehand… If this is an exploratory study, pick out the best (minimum AIC). Not only in Smith’s example I found no relevant difference between w=1, w=1/ x, and w=1/ x². Boca Raton: Chapman & Hall / CRC Press 2009. Design and Analysis of Bioavailability and Bioequivalence Studies. I followed suggestions by Chow/Liu (Chow SC, Liu JP. Did Simth use the BE method for Camx/Dose vs Dose? If yes, why there is only 1 Rdnm for 4 difference doses? I am confused.Įdited by LLLi, 11 November 2016 - 04:43 PM. In Helmut's unweighted example (also the example 1 in Smith's paper), for the power model of ln(Cmax) vs ln(Dose), we only need to check if 90% CI is within the reference interval (which is dependent on r and H,L)? The paper used 0.8 and 1.25 becasue of the BE guideline?ģ) Furthermore, I can't understand the description of Rdnm in the paper. Why? That is the reason that Helmut used 1/x, not 1/(x*x), as weighting?Ģ) Another question is about the decision rules. I tried to use 1/(x*x) as weighting but only got information on intercept. There was also no difference of residuals plots. From the results, the weighting only changed the results of CIs a little bit, not the estimate. I have some queations about DP and hope to get your answeres.ġ) In Helmut's project, 1/x was used as weighting. 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