![]() ![]() In a confirmatory study you have to specify the weighting scheme beforehand… If this is an exploratory study, pick out the best (minimum AIC). Not only in Smith’s example I found no relevant difference between w=1, w=1/ x, and w=1/ x². Boca Raton: Chapman & Hall / CRC Press 2009. Design and Analysis of Bioavailability and Bioequivalence Studies. I followed suggestions by Chow/Liu (Chow SC, Liu JP. Did Simth use the BE method for Camx/Dose vs Dose? If yes, why there is only 1 Rdnm for 4 difference doses? I am confused.Įdited by LLLi, 11 November 2016 - 04:43 PM. In Helmut's unweighted example (also the example 1 in Smith's paper), for the power model of ln(Cmax) vs ln(Dose), we only need to check if 90% CI is within the reference interval (which is dependent on r and H,L)? The paper used 0.8 and 1.25 becasue of the BE guideline?ģ) Furthermore, I can't understand the description of Rdnm in the paper. Why? That is the reason that Helmut used 1/x, not 1/(x*x), as weighting?Ģ) Another question is about the decision rules. ![]() I tried to use 1/(x*x) as weighting but only got information on intercept. There was also no difference of residuals plots. From the results, the weighting only changed the results of CIs a little bit, not the estimate. I have some queations about DP and hope to get your answeres.ġ) In Helmut's project, 1/x was used as weighting.
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